Can a Freemason Resign?

Of course a man can resign from Freemasonry

Many men have so done for a variety of reasons.  

The man joined the Craft of his own free will and accord and he may leave the Craft on his own for whatever reason he wishes.  

If you should desire to resign from your Lodge in Pennsylvania click here. Follow the instructions if you wish to remain in Good Masonic Standing

I have no idea what is involved in other states or countries.

Before you resign you should also see:

How to resign conditionally from a Lodge in Pennsylvania.

Why Freemasons sometimes quit Freemasonry?